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Article

ESR2 regulates granulosa cell genes essential for follicle maturation and ovulation.

Molecular and cellular endocrinology - 15 Oct 2018

Khristi Vincentaben, Chakravarthi V Praveen, Singh Prabhakar, Ghosh Subhra, Pramanik Archit, Ratri Anamika, Borosha Shaon, Roby Katherine F, Wolfe Michael W, Rumi M A Karim

Abstract excerpt

Estrogen receptor 2 (ESR2) plays a critical role in folliculogenesis and ovulation. Disruption of ESR2-function in the rats results in female infertility due to failure of ovulation. Ovulation failure occurred in two distinct rat models, a null mutant and a DNA binding domain (DBD) mutant of ESR2, indicating that transcriptional regulation by ESR2 is indispensable for ovulation. To define the regulatory role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29580824
DOI: 10.1016/j.mce.2018.03.012

Genes

ESR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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