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Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2023

Luo Qiaoyan, Ling Zhifa, Huang Xiaojia, Zuo Ying

Abstract excerpt

Background: Insulin Receptor Substrate (IRS) molecules play a major role in insulin signalling, and single nucleotide polymorphisms in the IRS-1 (rs1801278) and IRS-2 (rs1805097) gene has been associated with the predisposition to the development of type-2 diabetes (T2D) in some population. However, the observations remain contradictory. Discrepancies in the results have been attributed to several factors, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37173295
DOI: 10.1080/15257770.2023.2211122

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