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Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro

12 Oct 2018

Abstract excerpt

Successful human spermatogonial stem cell (hSSC) culture could enable cell therapy for male infertility. Mammalian extracellular matrix (ECM) promotes mitogenesis, migration, and/or differentiation of various stem/progenitor cells, and can plausibly facilitate hSSC survival in culture. Hydrogel forms of human testicular ECM (htECM), porcine testicular ECM (ptECM), porcine small intestinal submucosa ECM (SIS), and...

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PMID: 30311859
DOI: 10.1089/ten.tea.2018.0147

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