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Article

Compound C inhibits nonsense-mediated RNA decay independently of AMPK

5 Oct 2018

Abstract excerpt

The nonsense mediated RNA decay (NMD) pathway safeguards the integrity of the transcriptome by targeting mRNAs with premature translation termination codons (PTCs) for degradation. It also regulates gene expression by degrading a large number of non-mutant RNAs (including mRNAs and noncoding RNAs) that bear NMD-inducing features. Consequently, NMD has been shown to influence development, cellular response to...

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PMID: 30289931
DOI: 10.1371/journal.pone.0204978

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