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Article

The mir‐200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves

2 Oct 2018

Abstract excerpt

BACKGROUND: An individual with a bicuspid aortic valve (BAV) runs a substantially higher risk of developing aneurysm in the ascending aorta compared to the normal population with tricuspid aortic valves (TAV). Aneurysm formation in patients with BAV and TAV is known to be distinct at the molecular level but the underlying mechanisms are undefined. Here, we investigated the still incompletely described role of...

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PMID: 30280445
DOI: 10.1111/joim.12833

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