Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum

Abstract excerpt

Abstract The ATP-binding cassette transporterABCB6was recently discovered to encode the Langereis (Lan) blood group antigen. Lan null individuals are asymptomatic, and the function of ABCB6 in mature erythrocytes is not understood. Here, we assessed ABCB6 as a host factor forPlasmodium falciparummalaria parasites during erythrocyte invasion. We show that Lan null erythrocytes are highly resistant to invasion byP....

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