Article
Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity.
mBio - 7 Jan 2020
Peng Yu-Chih, Qi Yanwei, Zhang Cui, Yao Xiangyu, Wu Jian, Pattaradilokrat Sittiporn, Xia Lu, Tumas Keyla C, He Xiao, Ishizaki Takahiro, Qi Chen-Feng, Holder Anthony A, Myers Timothy G, Long Carole A, Kaneko Osamu, Li Jian, Su Xin-Zhuan
Abstract excerpt
Erythrocyte-binding-like (EBL) proteins are known to play an important role in malaria parasite invasion of red blood cells (RBCs); however, any roles of EBL proteins in regulating host immune responses remain unknown. Here, we show that Plasmodium yoelii EBL (PyEBL) can shape disease severity by modulating the surface structure of infected RBCs (iRBCs) and host immune responses. We identified an amino acid...
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