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Article

ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis.

Nature genetics - 15 Jan 2012

Helias Virginie, Saison Carole, Ballif Bryan A, Peyrard Thierry, Takahashi Junko, Takahashi Hideo, Tanaka Mitsunobu, Deybach Jean-Charles, Puy Hervé, Le Gall Maude, Sureau Camille, Pham Bach-Nga, Le Pennec Pierre-Yves, Tani Yoshihiko, Cartron Jean-Pierre, Arnaud Lionel

Abstract excerpt

The human ATP-binding cassette (ABC) transporter ABCB6 has been described as a mitochondrial porphyrin transporter essential for heme biosynthesis, but it is also suspected to contribute to anticancer drug resistance, as do other ABC transporters located at the plasma membrane. We identified ABCB6 as the genetic basis of the Lan blood group antigen expressed on red blood cells but also at the plasma membrane of...

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Share to ATP-Binding Cassette Transporters
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Group Antigens

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Source

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Identifiers

PMID: 22246506
DOI: 10.1038/ng.1069
PMCID: PMC3664204

Genes

ABCB6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis.PMID 22246506Read ↗

Screening the expression of ABCB6 in erythrocytes reveals an unexpectedly high frequency of Lan mutations in healthy individuals.Semantic proximity Read ↗

Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparumSemantic proximity Read ↗

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.Semantic proximity Read ↗

Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation.Semantic proximity Read ↗

Molecular analysis of immunized Jr(a-) or Lan- patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a-) and Lan- phenotypes.Semantic proximity Read ↗

Alleles of the LAN blood group system: molecular and serologic investigations.Semantic proximity Read ↗

Molecular analysis of the rare in(Lu) blood type: toward decoding the phenotypic outcome of haploinsufficiency for the transcription factor KLF1.Semantic proximity Read ↗

Identification of human glycosyltransferase genes expressed in erythroid cells predicts potential carbohydrate blood group loci.Semantic proximity Read ↗

Novel mutations of ABCB6 associated with autosomal dominant dyschromatosis universalis hereditaria.Semantic proximity Read ↗

A new ABCG2 null allele with a 27-kb deletion including the promoter region causing the Jr(a-) phenotype.Semantic proximity Read ↗

Novel missense mutations of ABCB6 in two chinese families with dyschromatosis universalis hereditaria.Semantic proximity Read ↗

Missense mutations in the ABCB6 transporter cause dominant familialpseudohyperkalemiaSemantic proximity Read ↗

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