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Transcription factor ATF3 aggravates kidney fibrosis by maintaining the state of histone H3 lysine 27 acetylation

8 Feb 2025

Abstract excerpt

BACKGROUND: Chronic kidney disease (CKD) is a global health issue, with renal fibrosis being a common pathway in CKD development. Histone modification plays crucial roles in transcriptional regulation, but their pathological functions and mechanisms in CKD are not well understood. METHODS: We utilized chromatin immunoprecipitation with next-generation DNA sequencing (ChIP-seq) and RNA-seq to evaluate the states...

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PMID: 39920894
DOI: 10.1097/cm9.0000000000003425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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