Article
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.
Gut - 1 Dec 2016
Mima Kosuke, Nishihara Reiko, Qian Zhi Rong, Cao Yin, Sukawa Yasutaka, Nowak Jonathan A, Yang Juhong, Dou Ruoxu, Masugi Yohei, Song Mingyang, Kostic Aleksandar D, Giannakis Marios, Bullman Susan, Milner Danny A, Baba Hideo, Giovannucci Edward L, Garraway Levi A, Freeman Gordon J, Dranoff Glenn, Garrett Wendy S, Huttenhower Curtis, Meyerson Matthew, Meyerhardt Jeffrey A, Chan Andrew T, Fuchs Charles S, Ogino Shuji
Abstract excerpt
OBJECTIVE: Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome. DESIGN: We used molecular pathological epidemiology...
Topics
- Aged
- Biomarkers, Tumor
- Carcinoma
- Class I Phosphatidylinositol 3-Kinases
- Colorectal Neoplasms
- Databases, Factual
- Female
- Follow-Up Studies
- Fusobacterium nucleatum