Detection of Fusobacterium nucleatum in Colorectal Adenomas Reveals Associations with Immune Molecular Signatures.

doi:10.3390/ijms27167258

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Detection of Fusobacterium nucleatum in Colorectal Adenomas Reveals Associations with Immune Molecular Signatures.

International journal of molecular sciences - 14 Aug 2026

Al-Badran Sara Samir Foad, Fisher Natalie, Dunne Philip D, Johnstone Mark, Maka Noori, Rooney William M, Campbell Samantha, Capewell Paul, Andersen Ditte, Lynch Gerard, McSorley Stephen, Edwards Joanne

Abstract excerpt

Fusobacterium nucleatum has been implicated in colorectal cancer, but its role in adenomas remains unclear. We applied an RNA-based detection of F. nucleatum in formalin-fixed paraffin-embedded adenoma tissue and explored the mutational landscape and transcriptomic profile of F. nucleatum+ patients in comparison to F. nucleatum- patients. Bespoke F. nucleatum probes successfully detected F. nucleatum in 11% of...

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Adenoma
Aged
Colorectal Neoplasms
Gene Expression Profiling
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42653262
DOI: 10.3390/ijms27167258
PMCID: PMC13513411

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