Article
IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid.
Journal of autoimmunity - 1 Jan 2019
Chakievska Lenche, Holtsche Maike M, Künstner Axel, Goletz Stephanie, Petersen Britt-Sabina, Thaci Diamant, Ibrahim Saleh M, Ludwig Ralf J, Franke Andre, Sadik Christian D, Zillikens Detlef, Hölscher Christoph, Busch Hauke, Schmidt Enno
Abstract excerpt
IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease with a high need for more specific, effective and safe treatment options. The aim of this study was to clarify the...
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