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Article

Cytokine profiling reveals HLA-linked Th2 and Th17 driven immune activation in pemphigus vulgaris patients and genetically susceptible healthy controls.

Frontiers in immunology - 1 Jan 2024

Schwartz Rebekah R, Seiffert-Sinha Kristina, Sinha Animesh A

Abstract excerpt

Introduction: Cytokines and chemokines direct the inflammatory response and may serve as markers of immune dysregulation in Pemphigus vulgaris (PV), an autoimmune blistering skin disorder. Previous studies on limited numbers of patients and cytokine profiles in PV have produced equivocal results regarding the role these mediators play in disease. Methods: In this study, we interrogated serum samples from 116 PV...

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Identifiers

PMID: 39697331
DOI: 10.3389/fimmu.2024.1500231
PMCID: PMC11652493

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