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Article

Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury.

BMC musculoskeletal disorders - 15 Sept 2018

Bao Xinnan, Hu Xinyu

Abstract excerpt

BACKGROUND: Cartilage degradation would result in osteoarthritis (OA). p16INK4awas found in some age-related diseases. In this study, we aimed to determine the role of p16INK4a during OA and to investigate the underlying mechanisms. METHODS: Enzyme-linked immunosorbent assay (ELISA) was performed to test the activity of senescence-associated secretory phenotype (SASP). Real-time PCR (RT-PCR) and Western blot were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30219053
DOI: 10.1186/s12891-018-2253-x
PMCID: PMC6138916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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