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Article

Ambra1

1 Dec 2011

Abstract excerpt

Mutations in the gene for the E3 ubiquitin ligase Parkin are the most prevalent cause of autosomal recessive Parkinson disease (PD), an incurable neurodegenerative disorder. Parkin surveys mitochondrial quality by translocating to depolarized mitochondria and inducing their selective macroautophagic removal (mitophagy). We recently reported that Parkin interacts with Ambra1 (activating molecule in Beclin...

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Identifiers

PMID: 21921694
DOI: 10.4161/auto.7.12.17893

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Related research

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Ambra1PMID 21921694Read ↗

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1Semantic proximity Read ↗

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A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1Semantic proximity Read ↗

PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s DiseaseSemantic proximity Read ↗

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagySemantic proximity Read ↗

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