Article
The binding of Class II sRNA MgrR to two different sites on matchmaker protein Hfq enables efficient competition for Hfq and annealing to regulated mRNAs.
RNA (New York, N.Y.) - 1 Dec 2018
Kwiatkowska Joanna, Wroblewska Zuzanna, Johnson Kenneth A, Olejniczak Mikolaj
Abstract excerpt
MgrR is an Hfq-dependent sRNA, whose transcription is controlled by the level of Mg2+ ions in Escherichia coli MgrR belongs to Class II sRNAs because its stability in the cell is affected by mutations in Hfq differently than canonical, Class I sRNAs. Here, we examined the effect of mutations in RNA binding sites of Hfq on the kinetics of the annealing of MgrR to two different target mRNAs, eptB and ygdQ, by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.