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Article

β‐Arrestin1 enhances liver fibrosis through autophagy‐mediated Snail signaling

14 Sept 2018

Abstract excerpt

GPCR mediator β-arrestins (β-arr1 and β-arr2) regulate a variety of physiologic and pathologic processes, including hepatocellular carcinogenesis. However, the role of β-arrestins in liver fibrosis remains unknown. β-arr1, but not β-arr2, was upregulated in liver fibrotic tissues in both humans and mice; moreover, autophagy was increased. β-arr1 deficiency or autophagic inhibitor 3-methyladenine (3-MA)...

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PMID: 30216111
DOI: 10.1096/fj.201800828rr

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