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Article

Increased EZH2 expression during the adenoma‑carcinoma sequence in colorectal cancer

31 Jul 2018

Abstract excerpt

The adenoma-carcinoma sequence, the sequential mutation and deletion of various genes by which colorectal cancer progresses, is a well-established and accepted concept of colorectal cancer carcinogenesis. Proteins of the polycomb repressive complex 2 (PRC2) function as transcriptional repressors by trimethylating histone H3 at lysine 27; the activity of this complex is essential for cell proliferation and...

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Share to Colorectal Cancer Screening and Detection
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PMID: 30214616
DOI: 10.3892/ol.2018.9240

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