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Article

FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells.

International journal of molecular sciences - 11 Sept 2018

Torres Ángelo, Arriagada Valentina, Erices José Ignacio, Toro María de Los Ángeles, Rocha José Dellis, Niechi Ignacio, Carrasco Cristian, Oyarzún Carlos, Quezada Claudia

Abstract excerpt

Poor response to current treatments for glioblastoma has been attributed to the presence of glioblastoma stem-like cells (GSCs). GSCs are able to expel antitumor drugs to the extracellular medium using the multidrug resistance-associated protein 1 (MRP1) transporter. Tacrolimus (FK506) has been identified as an MRP1 regulator in differentiated glioblastoma (GBM) cells (non-GSCs); however, the effect of FK506 on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30208561
DOI: 10.3390/ijms19092697
PMCID: PMC6164673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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