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Article

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy.

Investigative ophthalmology & visual science - 20 Mar 2018

Bhutto Imran A, Ogura Shuntaro, Baldeosingh Rajkumar, McLeod D Scott, Lutty Gerard A, Edwards Malia M

Abstract excerpt

Purpose: Geographic atrophy (GA) is the late stage of non-neovascular age-related macular degeneration. A lack of animal models for GA has hampered treatment efforts. Presented herein is a rat model for GA using subretinal injection of sodium iodate (NaIO3). Methods: Rats were given subretinal injections of NaIO3 (5 μg/μL) using a pico-injector. Fundus photographs and spectral domain optical coherent tomography...

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Source

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Identifiers

PMID: 30208410
DOI: 10.1167/iovs.18-24245
PMCID: PMC6133234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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