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The MmpS6-MmpL6 Operon Is an Oxidative Stress Response System Providing Selective Advantage toMycobacterium tuberculosisin Stress

30 Aug 2018

Abstract excerpt

Background: The stress response adaptability of Mycobacterium tuberculosis (Mtb) is still unresolved. In this study, we ascribe an important function to the MmpS6-MmpL6 (M6) operon in Mtb stress management. Methods: By using a novel promoter probe in a high-throughput unbiased screen, we identified several quinones as potent inducers of the M6 operon in addition to triclosan. Results: Triclosan and plumbagin...

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PMID: 30203030
DOI: 10.1093/infdis/jiy526

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