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Article

Targeted Disruption of Aromatase Reveals Dual Functions of cyp19a1a During Sex Differentiation in Zebrafish.

Endocrinology - 1 Sept 2017

Yin Yike, Tang Haipei, Liu Yun, Chen Yu, Li Gaofei, Liu Xiaochun, Lin Haoran

Abstract excerpt

Aromatase (encoded by the cyp19a1a and cyp19a1b genes) plays a central role in sex differentiation in fish, but its precise roles during sex differentiation are still largely unknown. Here, we systematically generated cyp19a1a and cyp19a1b mutant lines as well as a cyp19a1a;cyp19a1b double mutant line in zebrafish using transcription activatorlike effector nucleases. Our results showed that cyp19a1a mutants and...

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PMID: 28575219
DOI: 10.1210/en.2016-1865

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