Article
Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase.
Biochemistry - 2 Oct 2018
Graham Brian W, Bougoulias Michael E, Dodge Katie L, Thaxton Carly T, Olaso Danae, Tao Yeqing, Young Nicolas L, Marshall Alan G, Trakselis Michael A
Abstract excerpt
A growing body of evidence supports a steric exclusion and wrapping model for DNA unwinding in which hexameric helicases interact with the excluded single-stranded DNA (ssDNA) in addition to the encircled strand. Interactions with the excluded ssDNA have been shown to be mediated primarily by electrostatic interactions, but base stacking with surface-exposed tyrosine residues is an alternative hypothesis. Here,...
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