Article
Platelet engraftment after allogenic stem cell transplantation is monitored by digital polymerase chain reaction without interference by platelet support.
Experimental hematology - 1 Dec 2018
Doescher Andrea, Casper Jochen, Kraemer Doris, Kapels Hans-Hermann, Petershofen Eduard K, Müller Thomas H
Abstract excerpt
Platelet engraftment after allogeneic hematopoietic stem cell transplantation is conventionally monitored by daily platelet counts. Platelet transfusions are frequently required and obscure the detection of platelet engraftment. Digital polymerase chain reaction (ddPCR) of mitochondrial DNA isolated from platelets reliably quantifies circulating platelets derived from the stem cell graft and allows us to...
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