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Article

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation.

Scientific reports - 21 Jan 2020

Kowalski Thayne Woycinck, Gomes Julia do Amaral, Garcia Gabriela Barreto Caldas, Fraga Lucas Rosa, Paixao-Cortes Vanessa Rodrigues, Recamonde-Mendoza Mariana, Sanseverino Maria Teresa Vieira, Schuler-Faccini Lavinia, Vianna Fernanda Sales Luiz

Abstract excerpt

The Cereblon-CRL4 complex has been studied predominantly with regards to thalidomide treatment of multiple myeloma. Nevertheless, the role of Cereblon-CRL4 in Thalidomide Embryopathy (TE) is still not understood. Not all embryos exposed to thalidomide develop TE, hence here we evaluate the role of the CRL4-Cereblon complex in TE variability and susceptibility. We sequenced CRBN, DDB1, CUL4A, IKZF1, and IKZF3 in...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31964914
DOI: 10.1038/s41598-020-57512-x
PMCID: PMC6972723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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