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Article

Sendai virus C protein limits NO production in infected RAW264.7 macrophages.

Innate immunity - 1 Oct 2018

Odkhuu Erdenezaya, Komatsu Takayuki, Koide Naoki, Naiki Yoshikazu, Takeuchi Kenji, Tanaka Yukie, Tsolmongyn Bilegtsaikhan, Jambalganiin Ulziisaikhan, Morita Naoko, Yoshida Tomoaki, Gotoh Bin, Yokochi Takashi

Abstract excerpt

To suppress virus multiplication, infected macrophages produce NO. However, it remains unclear how infecting viruses then overcome NO challenge. In the present study, we report the effects of accessory protein C from Sendai virus (SeV), a prototypical paramyxovirus, on NO output. We found that in RAW264.7 murine macrophages, a mutant SeV without C protein (4C(-)) significantly enhanced inducible NO synthase...

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Identifiers

PMID: 30189760
DOI: 10.1177/1753425918796619
PMCID: PMC6830875

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