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Article

An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction.

FEBS letters - 3 Jan 2014

Yamaguchi Mayu, Kitagawa Yoshinori, Zhou Min, Itoh Masae, Gotoh Bin

Abstract excerpt

Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti-IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN-α promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll-like receptor (TLR) 7- and TLR9-dependent IFN-α induction, which is specific to plasmacytoid dendritic...

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Identifiers

PMID: 24269682
DOI: 10.1016/j.febslet.2013.11.015

Genes

TLR9

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