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Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon‐α/β‐mediated responses

5 Oct 1999

Abstract excerpt

Sendai virus (SeV) renders cells unresponsive to interferon (IFN)-alpha. To identify viral factors involved in this process, we examined whether recombinant SeVs, which could not express V protein, subsets of C proteins (C, C', Y1 and Y2) or any of four C proteins, retained the capability of impeding IFN-alpha-mediated responses. Among these viruses, only the 4C knockout virus completely lost the ability to...

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PMID: 10518019
DOI: 10.1016/s0014-5793(99)01241-7

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