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Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells

5 Sept 2018

Abstract excerpt

BACKGROUND: Adipose-tissue stem cells (ASCs) are subject of intensive research since their successful use in regenerative therapy. The drawback of ASCs is that they may serve as stroma for cancer cells and assist tumor progression. It is disquieting that ASCs frequently undergo genetic and epigenetic changes during their in vitro propagation. In this study, we describe the polyploidization of murine ASCs and the...

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PMID: 30185144
DOI: 10.1186/s12885-018-4781-z

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