Human adipose-derived mesenchymal stromal cells from face and abdomen undergo replicative senescence and loss of genetic integrity after long-term culture.

doi:10.1016/j.yexcr.2021.112740

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Article

Human adipose-derived mesenchymal stromal cells from face and abdomen undergo replicative senescence and loss of genetic integrity after long-term culture.

Experimental cell research - 1 Sept 2021

Delben Priscilla Barros, Zomer Helena Debiazi, Acordi da Silva Camila, Gomes Rogério Schutzler, Melo Fernanda Rosene, Dillenburg-Pilla Patricia, Trentin Andrea Gonçalves

Abstract excerpt

Body fat depots are heterogeneous concerning their embryonic origin, structure, exposure to environmental stressors, and availability. Thus, investigating adipose-derived mesenchymal stromal cells (ASCs) from different sources is essential to standardization for future therapies. In vitro amplification is also critical because it may predispose cell senescence and mutations, reducing regenerative properties and...

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PMID: 34303697
DOI: 10.1016/j.yexcr.2021.112740

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