Article
TP53 mutations are associated with mutated MYD88 and CXCR4, and confer an adverse outcome in Waldenström macroglobulinaemia.
British journal of haematology - 1 Jan 2019
Gustine Joshua N, Tsakmaklis Nicholas, Demos Maria G, Kofides Amanda, Chen Jiaji G, Liu Xia, Munshi Manit, Guerrera Maria L, Chan Gloria G, Patterson Christopher J, Meid Kirsten, Dubeau Toni, Yang Guang, Hunter Zachary R, Treon Steven P, Castillo Jorge J, Xu Lian
Abstract excerpt
Little is known about TP53 mutations in Waldenström Macroglobulinaemia (WM). We evaluated 265 WM patients for TP53 mutations by next-generation sequencing, and validated the findings by Sanger sequencing. TP53 mutations were identified and validated in 6 (2·6%) patients that impacted the DNA-binding domain. All six were MYD88- and CXCR4-mutated. Ibrutinib showed activity in patients carrying all three mutations....
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