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Article

Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.

Cancer discovery - 1 Nov 2018

Jia Deshui, Augert Arnaud, Kim Dong-Wook, Eastwood Emily, Wu Nan, Ibrahim Ali H, Kim Kee-Beom, Dunn Colin T, Pillai Smitha P S, Gazdar Adi F, Bolouri Hamid, Park Kwon-Sik, MacPherson David

Abstract excerpt

CREBBP, encoding an acetyltransferase, is among the most frequently mutated genes in small cell lung cancer (SCLC), a deadly neuroendocrine tumor type. We report acceleration of SCLC upon Crebbp inactivation in an autochthonous mouse model. Extending these observations beyond the lung, broad Crebbp deletion in mouse neuroendocrine cells cooperated with Rb1/Trp53 loss to promote neuroendocrine thyroid and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30181244
DOI: 10.1158/2159-8290.CD-18-0385
PMCID: PMC6294438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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