Novel mutant P277 peptide VP to ameliorate atherogenic side-effects and to preserve anti-diabetic effects in NOD mice.

doi:10.1016/j.yexcr.2018.08.034

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Article

Novel mutant P277 peptide VP to ameliorate atherogenic side-effects and to preserve anti-diabetic effects in NOD mice.

Experimental cell research - 15 Oct 2018

Zhang Yanfeng, Lu Shiping, Alahdal Murad, Gao Huashan, Shen Yumeng, Pan Yi, Wu Jie, Xing Yun, Jin Liang

Abstract excerpt

P277 is a 24 amino-acids peptide, residues 437-460 of human heat shock protein 60 (HSP60). P277 or sequence repeated 6 × P277 was previously found showing potency preventive and therapeutic anti-diabetes functions in NOD mice, but aroused atherosclerosis due to the induction of anti-HSP65 autoantibodies as reported. To determine the intrinsic B epitope sequence, we screened P277 with pepscan method and then...

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PMID: 30179603
DOI: 10.1016/j.yexcr.2018.08.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.