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Article

Pathophysiology of diverticular disease.

Expert review of gastroenterology & hepatology - 1 Jul 2018

Schieffer Kathleen M, Kline Bryan P, Yochum Gregory S, Koltun Walter A

Abstract excerpt

INTRODUCTION: Inflammation of diverticula, or outpouchings of the colonic mucosa and submucosa through the muscularis layer, leads to diverticulitis. The development of diverticular disease, encompassing both diverticulosis and diverticulitis, is a result of genetic predisposition, lifestyle, and environmental factors, including the microbiome. Areas covered: Previous reports implicated genetic predisposition,...

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PMID: 29846097
DOI: 10.1080/17474124.2018.1481746

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