Article
Visualizing Genetic Variants, Short Targets, and Point Mutations in the Morphological Tissue Context with an RNA In Situ Hybridization Assay.
Journal of visualized experiments : JoVE - 14 Aug 2018
Anderson Courtney M, Laeremans Annelies, Wang Xiao-Ming Mindy, Wu Xingyong, Zhang Bingqing, Doolittle Emerald, Kim Jeffrey, Li Na, Pimentel Helly Xiao Yan, Park Emily, Ma Xiao-Jun
Abstract excerpt
Because precision medicine is highly dependent on the accurate detection of biomarkers, there is an increasing need for standardized and robust technologies that measure RNA biomarkers in situ in clinical specimens. While grind-and-bind assays like RNAseq and quantitative RT-PCR enable highly sensitive gene expression measurements, they also require RNA extraction and thus prevent valuable expression analysis...
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