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Article

Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease.

Molecular neurobiology - 1 May 2019

Esteves Sofia, Oliveira Stéphanie, Duarte-Silva Sara, Cunha-Garcia Daniela, Teixeira-Castro Andreia, Maciel Patrícia

Abstract excerpt

Spinocerebellar ataxias are dominantly inherited neurodegenerative disorders with no disease-modifying treatment. We previously identified the selective serotonin reuptake inhibitor citalopram as a safe and effective drug to be repurposed for Machado-Joseph disease. Pre-symptomatic treatment of transgenic (CMVMJD135) mice strikingly ameliorated mutant ataxin-3 (ATXN3) pathogenesis. Here, we asked whether...

Topics

Animals
Ataxin-3
Citalopram
Gait
Machado-Joseph Disease
Mice, Inbred C57BL
Mice, Transgenic
Motor Activity
Neuroprotective Agents
Phenotype
Trinucleotide Repeat Expansion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30173407
DOI: 10.1007/s12035-018-1332-1

Genes

ATXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Machado-Joseph Disease.PMID 30173407Read ↗

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