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Article

AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency.

Thyroid : official journal of the American Thyroid Association - 1 Jul 2022

Liao Xiao-Hui, Avalos Pablo, Shelest Oksana, Ofan Raz, Shilo Michael, Bresee Catherine, Likhite Shibi, Vit Jean-Philippe, Heuer Heike, Kaspar Brian, Meyer Kathrin, Dumitrescu Alexandra M, Refetoff Samuel, Svendsen Clive N, Vatine Gad D

Abstract excerpt

Background: Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor disability disorder that also manifests characteristic abnormal thyroid hormone (TH) levels. AHDS is caused by inactivating mutations in monocarboxylate transporter 8 (MCT8), a specific TH plasma membrane transporter widely expressed in the central nervous system (CNS). MCT8 mutations cause impaired transport of TH across brain barriers,...

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Identifiers

PMID: 35350867
DOI: 10.1089/thy.2022.0034
PMCID: PMC9469747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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