Article
Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.
Scientific reports - 16 Dec 2016
Liu Yan, Zhi Dejuan, Li Menghui, Liu Dongling, Wang Xin, Wu Zhengrong, Zhang Zhanxin, Fei Dongqing, Li Yang, Zhu Hongmei, Xie Qingjian, Yang Hui, Li Hongyu
Abstract excerpt
Since about 30% of all human cancers contain mutationally activated Ras, down regulating the over-activation of Ras/MAPK pathway represents a viable approach for treating cancers. Over-activation of Ras/MAPK pathway is accompanied by accumulation of reactive oxygen species (ROS). One approach for developing anti-cancer drugs is to target ROS production and their accumulation. To test this idea, we have employed...
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