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Article

SH3‐class Ras guanine nucleotide exchange factors are essential forAspergillus fumigatusinvasive growth

30 Jan 2019

Abstract excerpt

Proper hyphal morphogenesis is essential for the establishment and progression of invasive disease caused by filamentous fungi. In the human pathogen Aspergillus fumigatus, signalling cascades driven by Ras and Ras-like proteins orchestrate a wide variety of cellular processes required for hyphal growth. For activation, these proteins require interactions with Ras-subfamily-specific guanine nucleotide exchange...

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PMID: 30698898
DOI: 10.1111/cmi.13013

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