A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype.

doi:10.1038/322474a0

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Article

A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype.

Nature - 1 Jan 2000

Pologe L G, Ravetch J V

Abstract excerpt

The significant morbidity and mortality associated with Plasmodium falciparum malaria results, in part, from the sequestration of parasitized erythrocytes in postcapillary venules, which may protect the parasite from splenic clearance and contribute to the pathogenesis of cerebral malaria. This s...

Topics

Chromosome Mapping
DNA
DNA Restriction Enzymes
Humans
Mutation
Peptides
Phenotype
Plasmodium falciparum
Proteins
Protozoan Proteins
Recombination, Genetic
Histidine-Rich Glycoprotein

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