Cloning and characterization of chromosome breakpoints of<i>Plasmodium falciparum</i>: breakage and new telomere formation occurs frequently and randomly in subtelomeric genes

Abstract excerpt

We analysed the genetic stability of two subtelomeric genes of the human malaria parasite Plasmodium falciparum. A PCR based assay, using a telomere and a target-gene specific primer was used to detect potential chromosome rearrangements. We show that chromosome breakage and the formation of new telomeres occur frequently in the two genes coding for histidine rich proteins (HRP I and HRP II) in laboratory...

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