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Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence

6 Oct 2021

Abstract excerpt

The pathology associated with malaria infection is largely due to the ability of infected human RBCs to adhere to a number of receptors on endothelial cells within tissues and organs. This phenomenon is driven by the export of parasite-encoded proteins to the host cell, the exact function of many of which is still unknown. Here we inactivate the function of one of these exported proteins, PFA66, a member of the...

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PMID: 34614006
DOI: 10.1371/journal.ppat.1009969

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