Article
ALS-associated genes display CNS expression in the developing zebrafish.
Gene expression patterns : GEP - 1 Dec 2018
Laboissonniere Lauren A, Smith Courtney L, Mesenbrink Jacquelyn, Chowdhury Rebecca, Burney Abbie, Lang Margaret, Sierra Matthew, Stark Amy, Maldonado-Casalduc Gabriel, Muller Madison, Trimarchi Jeffrey M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle atrophy resulting from the deterioration of motor neurons in the central nervous system (CNS). Recent genome-wide association studies have revealed several genes linked to ALS, further demonstrating the complexity of the disease. The zebrafish (Danio rerio) is an attractive model organism to study the function of the rapidly expanding...
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