Article
A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease.
Disease models & mechanisms - 1 Jan 2000
Ramesh Tennore, Lyon Alison N, Pineda Ricardo H, Wang Chunping, Janssen Paul M L, Canan Benjamin D, Burghes Arthur H M, Beattie Christine E
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that, for approximately 80% of patients, is fatal within five years of diagnosis. To better understand ALS, animal models have been essential; however, only rodent models of ALS exhibit the major hallmarks of the disease. Here, we report the generation of transgenic zebrafish overexpressing mutant Sod1. The construct used to generate...
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