Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced levels of ALS gene DCTN1 induce motor defects in Drosophila

9 Jun 2023

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neuromuscular disease that has a strong genetic component. Deleterious variants in the DCTN1 gene are known to be a cause of ALS in diverse populations. DCTN1 encodes the p150 subunit of the molecular motor dynactin which is a key player in the bidirectional transport of cargos within cells. Whether DCTN1 mutations lead to the disease through either a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37360176
DOI: 10.3389/fnins.2023.1164251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced levels of ALS gene DCTN1 induce motor defects in DrosophilaPMID 37360176Read ↗

Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression.Semantic proximity Read ↗

Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin.Semantic proximity Read ↗

DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.Semantic proximity Read ↗

Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1Semantic proximity Read ↗

Analysis of pre-symptomatic <i>Drosophila</i> models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degenerationSemantic proximity Read ↗

Biallelic inactivating variants in the chromatin remodeler DMAP1 cause a syndromic neurodevelopmental disorder.Semantic proximity Read ↗

Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profileSemantic proximity Read ↗

ALS-Associated KIF5A Mutation Causes Locomotor Deficits Associated with Cytoplasmic Inclusions, Alterations of Neuromuscular Junctions, and Motor Neuron Loss.Semantic proximity Read ↗

Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs.Semantic proximity Read ↗

Deregulations of miR‐1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1Semantic proximity Read ↗

Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans.Semantic proximity Read ↗

DYX1C1 is required for axonemal dynein assembly and ciliary motility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.