Article
Sleep phenotype in the Townes mouse model of sickle cell disease.
Sleep & breathing = Schlaf & Atmung - 1 Mar 2019
O'Donnell Brett J, Guo Lanping, Ghosh Samit, Shah Faraaz A, Strollo Patrick J, McVerry Bryan J, Gladwin Mark T, Ofori-Acquah Solomon F, Kato Gregory J, O'Donnell Christopher P
Abstract excerpt
PURPOSE: Patients with sickle cell disease (SCD) regularly experience abnormal sleep, characterized by frequent arousals and reduced total sleep time. However, obstructive sleep apnea syndrome (OSAS) is a common comorbidity of SCD, making it unclear whether the disease per se is impacting sleep, or sleep disruption is secondary to the presence of OSAS. Thus, we assessed sleep, independent of OSAS, using a mouse...
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