Article
A Predominant Variable-Number Tandem-Repeat Cluster of Mycobacterium tuberculosis Isolates among Asylum Seekers in the Netherlands and Denmark, Deciphered by Whole-Genome Sequencing.
Journal of clinical microbiology - 1 Feb 2018
Jajou Rana, de Neeling Albert, Rasmussen Erik Michael, Norman Anders, Mulder Arnout, van Hunen Rianne, de Vries Gerard, Haddad Walid, Anthony Richard, Lillebaek Troels, van der Hoek Wim, van Soolingen Dick
Abstract excerpt
In many countries, Mycobacterium tuberculosis isolates are routinely subjected to variable-number tandem-repeat (VNTR) typing to investigate M. tuberculosis transmission. Unexpectedly, cross-border clusters were identified among African refugees in the Netherlands and Denmark, although transmission in those countries was unlikely. Whole-genome sequencing (WGS) was applied to analyze transmission in depth and to...
Topics
- Adolescent
- Adult
- Africa
- Aged
- Child
- Cluster Analysis
- DNA, Bacterial
- Denmark
- Female
- Genome, Bacterial