Article
Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse.
American journal of human genetics - 12 Feb 2010
Odeh Hana, Hunker Kristina L, Belyantseva Inna A, Azaiez Hela, Avenarius Matthew R, Zheng Lili, Peters Linda M, Gagnon Leona H, Hagiwara Nobuko, Skynner Michael J, Brilliant Murray H, Allen Nicholas D, Riazuddin Saima, Johnson Kenneth R, Raphael Yehoash, Najmabadi Hossein, Friedman Thomas B, Bartles James R, Smith Richard J H, Kohrman David C
Abstract excerpt
Recessive mutations at the mouse pirouette (pi) locus result in hearing loss and vestibular dysfunction due to neuroepithelial defects in the inner ear. Using a positional cloning strategy, we have identified mutations in the gene Grxcr1 (glutaredoxin cysteine-rich 1) in five independent allelic...
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