Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2007

Hossain Zakir, Ali Safiah Mohamed, Ko Hui Ling, Xu Jianliang, Ng Chee Peng, Guo Ke, Qi Zeng, Ponniah Sathivel, Hong Wanjin, Hunziker Walter

Abstract excerpt

Wwtr1 is a widely expressed 14-3-3-binding protein that regulates the activity of several transcription factors involved in development and disease. To elucidate the physiological role of Wwtr1, we generated Wwtr1-/- mice by homologous recombination. Surprisingly, although Wwtr1 is known to regulate the activity of Cbfa1, a transcription factor important for bone development, Wwtr1-/- mice show only minor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Kidney

Share to Kidney Diseases, Cystic

Share to RNA, Small Interfering

Share to Tuberous Sclerosis Complex 1 Protein

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17251353
DOI: 10.1073/pnas.0605266104
PMCID: PMC1785239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.PMID 17251353Read ↗

Towards an understanding of kidney diseases associated with WT1 mutations.Semantic proximity Read ↗

Clinical Aspects of WT1 and the Kidney.Semantic proximity Read ↗

Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.Semantic proximity Read ↗

New insights into the function of the Wilms tumor suppressor geneWT1in podocytesSemantic proximity Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.Semantic proximity Read ↗

Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.Semantic proximity Read ↗

A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.Semantic proximity Read ↗

Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease.Semantic proximity Read ↗

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms’ Tumor 1 Target Genes in Podocyte Differentiation and MaintenanceSemantic proximity Read ↗

Ciliary ARL13B drives renal cystogenesis via its GEF activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.