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Essential role of Ahnak in adipocyte differentiation leading to the transcriptional regulation of Bmpr1α expression

28 Aug 2018

Abstract excerpt

The role of Ahnak in obesity has been reported previously. Loss of Ahnak leads to decreased Bmp4/Smad1 signaling, resulting in the downregulation of adipocyte differentiation. However, the biological significance of Ahnak remains largely unknown. In this study, we demonstrate that Ahnak-mediated impaired adipogenesis results in decreased Bmpr1α transcriptional expression. To confirm this, Ahnak siRNA was used to...

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PMID: 30154465
DOI: 10.1038/s41419-018-0873-6

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